Leukodystrophy on Brain CT and MRI: A Rare but Devastating White Matter Disease
Leukodystrophy on Brain CT and MRI: A Rare but Devastating White Matter Disease Author : Dr. S.B. Lee Introduction Leukodystrophies are a group of rare, progressive genetic disorders that affect the white matter of the brain and spinal cord. Characterized by abnormal development or destruction of myelin, the protective sheath surrounding nerve fibers, these diseases result in a spectrum of neurological impairments. This article focuses on the brain CT and MRI findings of leukodystrophy, illustrated by a 30-year-old male patient. The radiological features are discussed along with pathophysiological mechanisms, epidemiology, clinical manifestations, and the latest therapeutic strategies. Case Presentation A 30-year-old man underwent brain CT for evaluation of progressive cognitive decline. Compared to normal axial slices through the midbrain, the patient's images revealed: · Global ventricular enlargement and...