MediAI

  A Rare Case of Acquired Thrombotic Thrombocytopenic Purpura (TTP) in a 49-Year-Old Woman Un caso raro de púrpura trombocitopénica trombótica adquirida (PTT) en una mujer de 49 años 49세 여성의 희귀한 후천성 혈전성 혈소판감소성 자반증(TTP) 사례 Introduction Loss of consciousness (LOC) in an adult demands urgent evaluation due to its potentially life-threatening etiologies. When accompanied by thrombocytopenia and neurologic symptoms, the differential narrows, pointing to conditions such as thrombotic microangiopathies. We present a complex and instructive case involving a 49-year-old woman whose abrupt LOC at work led to the diagnosis of acquired thrombotic thrombocytopenic purpura (TTP).  Clinical Presentation A 49-year-old woman was found unconscious next to a photocopier at her workplace around 4:30 PM. Emergency services noted that she was aphasic and responded only with "yes" or "no". Her vitals were stable: temperature 36.3°C, heart rate 70 bpm, BP 141/98 mmHg, RR 18/min, SpO2 96% o...

  Thrombotic Thrombocytopenic Purpura in a 49-Year-Old Woman: A Comprehensive Case-Based Analysis Introduction Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening hematologic disorder characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and frequently neurologic symptoms. This article presents a detailed case study of a 49-year-old woman who presented to the emergency department with loss of consciousness and thrombocytopenia. The aim is to guide clinicians through the diagnostic process, highlight critical laboratory and imaging findings, and discuss evidence-based management strategies, including therapeutic plasma exchange. Case Presentation A 49-year-old woman was found unconscious at her workplace beside the photocopier. Initial assessment showed confusion, aphasia (only able to say "yes" or "no"), and no evidence of trauma. Her medical history included hypertension treated with amlodipine. Notably, she had recovered fr...