Primary Breast Lymphoma in a Young Woman with a Painless Breast Mass
Multimodality Imaging with Ultrasound, MRI, and FDG PET/CT Clinical Overview A painless breast mass in a young woman is often considered likely to represent a benign lesion such as fibroadenoma. However, when a mass demonstrates rapid growth, marked vascularity, atypical enhancement, or increased FDG uptake , a broader differential diagnosis should be considered. Primary breast lymphoma (PBL) is a rare extranodal non-Hodgkin lymphoma involving the breast. Although uncommon, it can mimic both benign breast tumors and primary breast carcinoma on imaging. This case is particularly noteworthy because of the combination of: Young age Immunosuppressive therapy Painless breast mass Hypervascular hypoechoic mass on ultrasound Tubular enhancement and washout kinetics on MRI Increased FDG uptake on PET/CT Final diagnosis of primary breast lymphoma, marginal zone lymphoma The case emphasizes the importance of integrating clinical history with multimodality breast imaging rather than relying on a...
