Zinner syndrome
Zinner syndrome Zinner Syndrome Overview Zinner syndrome is a rare congenital malformation of the male genitourinary tract, characterized by the classic triad of: Unilateral renal agenesis Ipsilateral seminal vesicle cyst Ejaculatory duct obstruction It is considered the male counterpart of the Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome in females. 1. Cause and Etiology Zinner syndrome results from abnormal development of the mesonephric (Wolffian) duct during embryogenesis, particularly between the 4th and 13th weeks of gestation. Mesonephric duct derivatives in males include: Epididymis Vas deferens Seminal vesicle Ejaculatory duct Trigone of the bladder Ureteric bud (which forms the ureter, renal pelvis, calyces, and collecting ducts) In Zinner syndrome, there is maldevelopment or failure of the ureteric bud to induce the metanephric blastema , leading to unilateral renal agenesis . Simultaneously, the malfor...