MediAI

  Keywords: Plasmacytoma, Solitary Plasmacytoma, Extramedullary Plasmacytoma, Skull Tumor, Plasma Cell Neoplasm, CT Imaging, Cranial Mass, Oncology, Radiology, Hematologic Malignancy   Abstract Plasmacytoma is a rare plasma cell neoplasm characterized by monoclonal proliferation of terminally differentiated B lymphocytes. Unlike multiple myeloma, plasmacytoma typically presents as a solitary mass in bone or soft tissue. This article provides an in-depth expert-level review of plasmacytoma, incorporating pathophysiology, epidemiology, clinical manifestations, advanced imaging characteristics, differential diagnosis, diagnostic strategies, therapeutic approaches, and prognosis. A representative case involving a painless scalp mass with destructive cranial involvement is presented, accompanied by radiologic interpretation and surgical management insights. Finally, clinical quiz questions and evidence-based references are included to enhance understanding and knowledge retent...

  Abstract Meningiomas are the most prevalent primary intracranial neoplasms, accounting for approximately one-third of all brain tumors.  Despite their generally benign nature, they may cause significant morbidity due to mass effect and involvement of critical neurovascular structures.  This column presents a comprehensive, evidence-based overview of meningioma pathophysiology, epidemiology, clinical manifestations, imaging characteristics, differential diagnosis, management strategies, and prognosis.  A representative case of a 78-year-old female patient with a calcified temporal meningioma is discussed with imaging illustrations.  The content is aligned with recent landmark publications, including the WHO 2021 CNS classification and contemporary neuro-oncology literature. Case Presentation A 78-year-old woman was admitted with progressively worsening nausea and dizziness over several months.  Episodes of brief unresponsiveness and staring were noted...