MediAI

  DOI: 10.1056/NEJMcps2307935 Introduction Hereditary Angioedema (HAE) is a rare but potentially life-threatening autosomal dominant disorder characterized by recurrent episodes of swelling in various parts of the body, including the skin, gastrointestinal tract, and upper airways. Despite its rarity, affecting approximately 1 in 50,000 individuals worldwide, the impact of HAE on patient quality of life is profound. Misdiagnosis and diagnostic delay remain common, with many patients experiencing years of symptoms before accurate identification. This article presents a comprehensive overview of hereditary angioedema including pathophysiology, epidemiology, clinical presentation, imaging features, differential diagnosis, diagnostic work-up, treatment, and prognosis . A real clinical case of a 19-year-old male presenting with recurrent abdominal pain is integrated into the discussion, with imaging findings and figure references provided for deeper understanding. Pathophysiolog...