MediAI

  Abstract Intussusception is a critical gastrointestinal condition characterized by the telescoping of one bowel segment into another, often leading to obstruction, ischemia, and potential perforation. While predominantly observed in pediatric populations, adult intussusception represents a diagnostically challenging and clinically significant entity, frequently associated with a pathological lead point such as malignancy. This article provides a comprehensive, expert-level review of intussusception, integrating clinical insights from a real-world case involving a 54-year-old male patient. Emphasis is placed on pathophysiology, epidemiology, clinical presentation, imaging features, differential diagnosis, diagnostic strategies, treatment modalities, and prognosis. Additionally, radiologic interpretation of CT imaging—including the hallmark “target sign”—is explored in depth.  Keywords Intussusception, Intussusception CT target sign, Adult intussusception diagnosis, Intus...