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When PSA Rises but Bone Scan Is Negative: The Critical Role of 18F-FDHT PET/CT in Re-staging Advanced Prostate Cancer

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  Clinical Hook An 86-year-old man had already endured years of treatment for advanced prostate cancer. His prostate-specific antigen (PSA) level began to rise again despite ongoing luteinizing hormone-releasing hormone (LHRH) agonist therapy. Surprisingly, the bone scan showed no evidence of metastatic disease. For many clinicians, a normal bone scan might appear reassuring. Yet the patient's biochemical profile suggested otherwise. Was this simply biochemical recurrence, or was metastatic disease hiding beyond the limits of conventional imaging? A subsequent 18F-FDHT PET/CT answered that question decisively. The examination revealed extensive lymph node metastases above and below the diaphragm, multiple skeletal metastases, and high androgen receptor (AR) expression throughout the metastatic lesions. Based on these findings, the patient's treatment strategy changed from continued hormonal suppression alone to consideration of androgen receptor antagonist therapy. This case ...

Giant Right Atrium: Multimodality Imaging Diagnosis with Chest X-ray, Echocardiography, Cardiac CT, MRI, and Artificial Intelligence

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Clinical Hook A 59-year-old man arrived at the emergency department because of progressively worsening bilateral leg edema. Although peripheral edema is commonly associated with chronic heart failure, the initial chest radiograph immediately attracted attention. Rather than pulmonary edema or left ventricular enlargement, the cardiac silhouette appeared dramatically enlarged toward the right side. His cardiothoracic ratio measured approximately 0.82 , indicating severe cardiomegaly. However, the enlargement was highly asymmetric. Instead of generalized cardiac enlargement, the right atrial contour dominated the cardiac silhouette, suggesting an unusual diagnosis rather than typical congestive heart failure. Further examination demonstrated: Newly diagnosed atrial fibrillation Functional tricuspid regurgitation Clinical signs of right-sided heart failure Preserved left ventricular systolic function These findings prompted comprehensive multimodality cardiovascular imaging, incl...