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Breast Cancer Metastasis Mimicking Osteoblastoma: The CT “Sequestralike Appearance” of a T12 Vertebral Lesion and the Role of MRI and 18F-FES PET/CT

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Introduction: When a “Benign-Looking” Vertebral Lesion Is Not Benign Back pain is one of the most common complaints encountered in clinical practice. In a young woman, particularly one in her twenties, the initial differential diagnosis often includes muscular strain, intervertebral disc disease, posture-related pain, or other benign musculoskeletal disorders. But medical imaging can completely change the clinical question. A small vertebral lesion may initially appear deceptively reassuring—or may resemble a rare benign bone tumor—until the patient's clinical history and tumor biology are incorporated into the interpretation. This is precisely what makes the present case so instructive. A woman in her late twenties presented with a history of persistent back pain. CT demonstrated an approximately 2-cm lucent lesion within the T12 vertebral body. The lesion contained a small internal osseous or calcific structure resembling a sequestrum. There was also cortical involvement and mild...
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Lymphangioleiomyomatosis (LAM): High-Resolution CT Diagnosis, Differential Diagnosis, Treatment, and Prognosis in a 40-Year-Old Woman

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Lymphangioleiomyomatosis: When Hundreds of Lung Cysts Tell the Diagnosis A 40-year-old woman has experienced gradually progressive shortness of breath for approximately two years. During the most recent four months, her symptoms have become substantially worse. At first glance, such a presentation could easily be attributed to asthma, deconditioning, chronic airway disease, or another common pulmonary disorder. But the clinical picture changes dramatically when a high-resolution chest CT reveals something striking: both lungs are filled with innumerable, relatively thin-walled cysts of varying sizes, extending from the upper lungs through the bases. This is the moment when medical imaging becomes more than a confirmatory test. It becomes the diagnostic language of the disease. The pattern strongly raises the possibility of lymphangioleiomyomatosis (LAM) , a rare multisystem disorder characterized by abnormal proliferation of LAM cells, progressive destruction of lung parenchyma, and f...
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