Abstract— Dystrophic calcinosis cutis represents a debilitating manifestation of connective tissue diseases (CTDs), characterized by the ectopic deposition of calcium salts in cutaneous and subcutaneous tissues despite normal serum calcium and phosphate levels. This article examines a clinical case of a 42-year-old female diagnosed with an overlap syndrome involving limited systemic sclerosis and dermatomyositis, presenting with progressive, extensive calcinosis. We explore the pathophysiology, including the role of chronic inflammation and tissue damage, and provide a detailed review of imaging features, differential diagnosis, and contemporary multi-modal treatment strategies. The integration of radiographic imaging and clinical history is emphasized as the gold standard for diagnosis. Keywords— Dystrophic Calcinosis Cutis, Systemic Sclerosis, Scleroderma, Dermatomyositis, Overlap Syndrome, Ectopic Calcification, Soft Tissue Imaging. I. Introduction Dystrophic calcinosis ...
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