Manganese Ferrite (MnFe2O4) based Magnetic Nano-Cluster for T2 Weighted 3T MR Imaging in Triple-Negative Breast Cancer
Manganese Ferrite (MnFe 2 O 4 ) based Magnetic Nano-Cluster for T 2 Weighted 3T MR Imaging in Triple-Negative Breast Cancer http://dx.doi.org/10.4283/JMAG.2025.30.1.6 Abstract In this study, we sought to develop Manganese Ferrite (MnFe 2 O 4 ) based Magnetic Nano-cluster (MNC) for specifically designed for the detection of triple-negative breast cancer (TNBC) through the use of magnetic resonance imaging (MRI). The MnFe2O4-based MNCs were synthesized utilizing a thermal decomposition method, which allowed for precise control over their structural properties. Following synthesis, the average size of the MNC was measured to be 69 ± 27.4 nm, a dimension that is optimal for effective imaging and cellular interactions. To evaluate the biocompatibility of the synthesized MNC, we conducted a series of cytotoxicity tests. These tests revealed that cellular viability remained above 82 % across all treatment concentrations, indicating that the MNCs exhibit minimal cytotoxi...