Swyer-James-MacLeod syndrome
Swyer-James-MacLeod syndrome 1. Definition Swyer-James-McLeod Syndrome (SJMS) is a rare, acquired pulmonary disorder characterized by post-infectious obliterative bronchiolitis leading to unilateral pulmonary hypoplasia, air trapping, and reduced vascular perfusion. It manifests as a hyperlucent lung or lobe, predominantly in children or young adults, often diagnosed incidentally or during evaluation for recurrent respiratory infections. 2. Etiology and Causes SJMS is considered an acquired condition , most commonly resulting from severe lower respiratory tract infections during early childhood , particularly in the first eight years of life , a critical period for alveolar and bronchial development. Causative Agents Adenovirus (especially types 3, 7, 21): Strongly implicated in obliterative bronchiolitis. ...