The Dual Threat: Navigating the Concurrence of Granulomatosis with Polyangiitis and Squamous Cell Carcinoma – A Diagnostic and Therapeutic Conundrum
Keywords: GRANULOMATOSIS WITH POLYANGIITIS , SQUAMOUS CELL CARCINOMA , ANCA-VASCULITIS , LUNG CANCER , DIAGNOSTIC CHALLENGE , PULMONARY VASCULITIS , COEXISTENCE The simultaneous presentation of a systemic autoimmune disease and a malignancy represents one of the most demanding diagnostic and therapeutic challenges in clinical medicine. Granulomatosis with polyangiitis (GPA), a severe form of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), rarely coexists with primary lung malignancies such as Squamous Cell Carcinoma (SCC). This complexity is amplified by the fact that both conditions can present with remarkably similar clinical and radiological features, often delaying a definitive diagnosis and complicating life-saving treatment strategies. We analyze a critical case of a 78-year-old male presenting with this dual pathology and delve into the pathophysiology, epidemiology, clinical presentation, imaging, diagnosis, treatment, and prognosis of this sinist...