Corkscrew Esophagus (Diffuse Esophageal Spasm): Advanced Imaging Diagnosis, Pathophysiology, and Clinical Management | Esophageal Motility Disorder SEO Guide
Abstract Corkscrew esophagus, classically associated with Diffuse Esophageal Spasm (DES), represents a rare but clinically significant esophageal motility disorder characterized by uncoordinated, high-amplitude contractions of the distal esophagus. This condition produces the hallmark radiologic appearance of a “corkscrew” or “rosary bead” esophagus on contrast esophagography. Despite its rarity, corkscrew esophagus remains a critical diagnostic consideration in patients presenting with intermittent dysphagia and non-cardiac chest pain. This column provides a comprehensive, expert-level review of corkscrew esophagus, including pathophysiology, epidemiology, clinical presentation, imaging findings, differential diagnosis, diagnostic modalities, treatment strategies, and prognosis, grounded in the latest global literature. A real-world case is presented with imaging correlation, followed by examination-style questions to reinforce learning. Keywords Corkscrew Esophagus, Diff...