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Large-Bowel Obstruction Induced by Hereditary Angioedema: A Case-Based Scientific Review Keywords : hereditary angioedema, large-bowel obstruction, C1 esterase inhibitor deficiency, abdominal angioedema, gastrointestinal edema, complement system disorder, bowel ischemia, bowel wall thickening Abstract Hereditary angioedema (HAE) is a rare, life-threatening genetic disorder characterized by episodes of severe swelling due to C1 esterase inhibitor (C1-INH) deficiency. While common manifestations include cutaneous and oropharyngeal edema, gastrointestinal involvement is frequently underrecognized. This article presents a case of large-bowel obstruction due to bowel wall edema secondary to HAE and discusses the underlying etiology, clinical presentation, imaging findings, and management strategies, with emphasis on the need for early recognition and appropriate long-term prophylaxis. Introduction Large-bowel obstruction (LBO) represents a surgical emergency with multiple potential e...