MediAI

  Keywords: Plasmacytoma, Solitary Plasmacytoma, Extramedullary Plasmacytoma, Skull Tumor, Plasma Cell Neoplasm, CT Imaging, Cranial Mass, Oncology, Radiology, Hematologic Malignancy   Abstract Plasmacytoma is a rare plasma cell neoplasm characterized by monoclonal proliferation of terminally differentiated B lymphocytes. Unlike multiple myeloma, plasmacytoma typically presents as a solitary mass in bone or soft tissue. This article provides an in-depth expert-level review of plasmacytoma, incorporating pathophysiology, epidemiology, clinical manifestations, advanced imaging characteristics, differential diagnosis, diagnostic strategies, therapeutic approaches, and prognosis. A representative case involving a painless scalp mass with destructive cranial involvement is presented, accompanied by radiologic interpretation and surgical management insights. Finally, clinical quiz questions and evidence-based references are included to enhance understanding and knowledge retent...