MediAI

  Sclerosing mesenteritis Sclerosing Mesenteritis (SM) is a rare, benign, and chronic inflammatory disorder that affects the mesenteric fat of the small intestine. It is characterized by chronic inflammation, fat necrosis, and fibrosis. 1. Cause (Etiology) The exact cause of sclerosing mesenteritis is unknown. It is considered idiopathic , although several potential associations have been proposed, including: Autoimmune disorders Prior abdominal surgery or trauma Infections Ischemia Malignancy (especially lymphomas and carcinomas) IgG4-related disease (in some cases) These factors may act as triggers in genetically or immunologically predisposed individuals. 2. Pathophysiology Sclerosing mesenteritis is a non-neoplastic inflammatory disorder involving the mesenteric fat. It evolves in three overlapping histological stages: Mesenteric Lipodystrophy : Dominated by fat necrosis with little or no inflammation. Mesenteric Panni...