Comprehensive Case Review of Juvenile Pilocytic Astrocytoma in a 5-Year-Old Girl with Gait Disturbance and Headache
Comprehensive Case Review of Juvenile Pilocytic Astrocytoma in a 5-Year-Old Girl with Gait Disturbance and Headache Introduction Juvenile pilocytic astrocytoma (JPA) is the most common pediatric cerebellar neoplasm and a subtype of glioma with typically indolent behavior. This expert-level column presents a comprehensive case of a 5-year-old girl presenting with headache and gait disturbance, ultimately diagnosed with JPA. We provide detailed radiologic-pathologic correlation, imaging features, diagnostic reasoning, differential diagnosis, and expert discussion on etiology, pathophysiology, epidemiology, clinical presentation, treatment, and prognosis of JPA. Case Summary A 5-year-old girl presented with a 1-month history of progressive gait abnormality and headache. A Head CT revealed a large heterogeneous mass in the posterior fossa with associated hydrocephalus. MRI showed a midline cerebellar mass with mixed solid and cystic components, peritumoral edema, loss of the fourth v...