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  Acute Sacroiliitis – Unilateral: A Comprehensive Clinical and Radiologic Review Keywords: Acute sacroiliitis, unilateral sacroiliitis, sacroiliac joint inflammation, MRI sacroiliitis, pelvic pain, infectious sacroiliitis, sacroiliitis treatment. Introduction Acute sacroiliitis is an inflammatory disorder involving one or both sacroiliac (SI) joints, with the unilateral form most commonly associated with infectious, reactive, or traumatic etiologies. The sacroiliac joint is a critical articulation that transmits axial loads from the spine to the pelvis and lower extremities, and inflammation here can cause profound pain and disability. In unilateral acute sacroiliitis, timely diagnosis is crucial because the underlying cause often requires urgent intervention — particularly in infectious cases. This post explores the cause, etiology, pathophysiology, epidemiology, clinical presentation, imaging characteristics, treatment, and prognosis of acute unilateral sacroiliitis, il...