Klebsiella pneumoniae Liver Abscess: Comprehensive Clinical, Imaging, and Therapeutic Review of Primary Liver Abscess Syndrome
Abstract Klebsiella pneumoniae liver abscess (KPLA) has emerged as one of the most clinically significant invasive bacterial infections in modern hepatobiliary medicine. Initially described predominantly in East Asia, this syndrome has increasingly been recognized worldwide due to globalization, diabetes prevalence, and evolving bacterial virulence factors. The disease represents a distinctive clinical entity characterized by primary liver abscess formation without preceding hepatobiliary disease, frequently accompanied by bacteremia and metastatic infections such as endophthalmitis, meningitis, and septic emboli. This column provides an expert-level review of Klebsiella pneumoniae primary liver abscess, integrating clinical insights with radiologic interpretation based on the provided case. The discussion explores pathophysiology, epidemiology, clinical manifestations, imaging characteristics, differential diagnosis, diagnostic strategies, treatment protocols,...